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The epigenetic mechanisms include methylation and/or demethylation of DNA, post-translational modifications of histones, and non-coding RNAs such as microRNAs (Casanello et al., 2018)

Small changes, shifting by a few hours, or moving to a different day, can make a meaningful difference

Additionally, the concurrent administration of corticosteroids (or ACTH) and testosterone can increase the likelihood of fluid retention and edema, which is particularly concerning in patients with heart failure or advanced liver disease